DO YOU KNOW FACTS ABOUT CANCER?
Cancer is the uncontrolled growth and spread of cells. It can affect
almost any part of the body. The growths often invade surrounding tissue
and can metastasize to distant sites. Many cancers can be prevented by
avoiding exposure to common risk factors, such as tobacco smoke. In
addition, a significant proportion of cancers can be cured, by surgery,
radiotherapy or chemotherapy, especially if they are detected early.
Cancer prevention
At least one-third of all cancer cases are
preventable. Prevention offers the most cost-effective long-term
strategy for the control of cancer.
Tobacco
Tobacco use is the single greatest avoidable risk factor for
cancer mortality worldwide, causing an estimated 22% of cancer deaths
per year. In 2004, 1.6 million of the 7.4 million cancer deaths were due
to tobacco use.
Tobacco smoking causes many types of cancer, including cancers of
the lung, esophagus, larynx (voice box), mouth, throat, kidney,
bladder, pancreas, stomach and cervix. About 70% of the lung cancer
burden can be attributed to smoking alone. Second-hand smoke (SHS), also
known as environmental tobacco smoke, has been proven to cause lung
cancer in nonsmoking adults. Smokeless tobacco (also called oral
tobacco, chewing tobacco or snuff) causes oral, esophageal and
pancreatic cancer.
Physical inactivity, dietary factors, obesity and being overweight
Dietary modification is another important approach to cancer
control. There is a link between overweight and obesity to many types of
cancer such as oesophagus, colorectum, breast, endometrium and kidney.
Diets high in fruits and vegetables may have a protective effect against
many cancers. Conversely, excess consumption of red and preserved meat
may be associated with an increased risk of colorectal cancer. In
addition, healthy eating habits that prevent the development of
diet-associated cancers will also lower the risk of cardiovascular
disease.
Regular physical activity and the maintenance of a healthy body
weight, along with a healthy diet, will considerably reduce cancer risk.
National policies and programmes should be implemented to raise
awareness and reduce exposure to cancer risk factors, and to ensure that
people are provided with the information and support they need to adopt
healthy lifestyles.
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WHO global strategy on diet, physical activity and health
Alcohol use
Alcohol use is a risk factor for many cancer types including
cancer of the oral cavity, pharynx, larynx, oesophagus, liver,
colorectum and breast. Risk of cancer increases with the amount of
alcohol consumed. The risk from heavy drinking for several cancer types
(e.g. oral cavity, pharynx, larynx and oesophagus) substantially
increases if the person is also a heavy smoker. Attributable fractions
vary between men and women for certain types of alcohol-related cancer,
mainly because of differences in average levels of consumption. For
example, 22% of mouth and oropharynx cancers in men are attributable to
alcohol whereas in women the attributable burden drops to 9%. A similar
sex difference exists for oesophageal and liver cancers (Rehm et al.,
2004).
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Global strategy to reduce harmful use of alcohol
Infections
Infectious agents are responsible for almost 22% of cancer deaths
in the developing world and 6% in industrialized countries. Viral
hepatitis B and C cause cancer of the liver; human papilloma virus
infection causes cervical cancer; the bacterium Helicobacter pylori
increases the risk of stomach cancer. In some countries the parasitic
infection schistosomiasis increases the risk of bladder cancer and in
other countries the liver fluke increases the risk of cholangiocarcinoma
of the bile ducts. Preventive measures include vaccination and
prevention of infection and infestation.
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Infectious diseases health topics
Environmental pollution
Environmental pollution of air, water and soil with carcinogenic
chemicals accounts for 1–4% of all cancers (IARC/WHO, 2003). Exposure to
carcinogenic chemicals in the environment can occur through drinking
water or pollution of indoor and ambient air. In Bangladesh, 5–10% of
all cancer deaths in an arsenic-contaminated region were attributable to
arsenic exposure (Smith, Lingas & Rahman, 2000). Exposure to
carcinogens also occurs via the contamination of food by chemicals, such
as afl atoxins or dioxins. Indoor air pollution from coal fires doubles
the risk of lung cancer, particularly among non-smoking women (Smith,
Mehta & Feuz, 2004). Worldwide, indoor air pollution from domestic
coal fires is responsible for approximately 1.5% of all lung cancer
deaths. Coal use in households is particularly widespread in Asia.
Occupational carcinogens
More than 40 agents, mixtures and exposure circumstances in the
working environment are carcinogenic to humans and are classified as
occupational carcinogens (Siemiatycki et al., 2004). That occupational
carcinogens are causally related to cancer of the lung, bladder, larynx
and skin, leukaemia and nasopharyngeal cancer is well documented.
Mesothelioma (cancer of the outer lining of the lung or chest cavity) is
to a large extent caused by work-related exposure to asbestos.
Occupational cancers are concentrated among specific groups of
the working population, for whom the risk of developing a particular
form of cancer may be much higher than for the general population. About
20–30% of the male and 5–20% of the female working-age population
(people aged 15–64 years) may have been exposed to lung carcinogens
during their working lives, accounting for about 10% of lung cancers
worldwide. About 2% of leukaemia cases worldwide are attributable to
occupational exposures.
Radiation
Ionizing radiation is carcinogenic to humans. Knowledge on
radiation risk has been mainly acquired from epidemiological studies of
the Japanese A-bomb survivors as well as from studies of medical and
occupational radiation exposure cohorts. Ionizing radiation can induce
leukaemia and a number of solid tumours, with higher risks at young age
at exposure. Residential exposure to radon gas from soil and building
materials is estimated to cause between 3% and 14% of all lung cancers,
making it the second cause of lung cancer after tobacco smoke. Radon
levels in homes can be reduced by improving the ventilation and sealing
floors and walls. Ionizing radiation is an essential diagnostic and
therapeutic tool. To guarantee that benefits exceed potential radiation
risks radiological medical procedures should be appropriately prescribed
and properly performed, to reduce unnecessary radiation doses,
particularly in children.
Ultraviolet (UV) radiation, and in particular solar radiation, is
carcinogenic to humans, causing all major types of skin cancer, such as
basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma.
Globally in 2000, over 200 000 cases of melanoma were diagnosed and
there were 65 000 melanoma-associated deaths. Avoiding excessive
exposure, use of sunscreen and protective clothing are effective
preventive measures. UV-emitting tanning devices are now also classified
as carcinogenic to humans based on their association with skin and
ocular melanoma cancers. (an article from WHO, www.who.int)